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Tubulin polymerization-IN-53

Tubulin polymerization-IN-53 (compound 4b) is an inhibitor of β-tubulin polymerization. Tubulin polymerization-IN-53 can arrest the cell cycle at the G2/M stage. Tubulin polymerization-IN-53 has antiproliferative efficacy against the MDA-MB-231 cell line with an IC50 value of 3.24 μM[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-53.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(OC)=C(C(OC)=C1)OC)N/C(C(O)=O)=C\C2=CC=C(C=C2)Cl

Molecular Formula

C19H18ClNO6

Molecular Weight

391.80

References & Citations

[1]Eman Fayad, et al. Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues. ACS Omega. 2023, 8,41.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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