Ru3
Ru3 is a poly (ADP-ribose) polymerase 1 inhibitor. Ru3 induces apoptosisin MCF-7 cells by multiple modes, inclusive of inducing DNA damage, suppressing DNA damage repair, disturbing cell cycle distribution, decreasing the mitochondrial membrane potential, and increasing the intracellular reactive oxygen species levels[1].
Product Specifications
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ru3.html
Solubility
10 mM in DMSO
Smiles
NC(S[Ru+]/123([N]4=CC=CC5=C4C6=[N]3C=CC=C6C7=NC8=CC9=C(C=C8N=C75)C=CC=C9)[N]%10=CC=CC=C%10C%11=[N]2C=CC=C%11)=N[N]1=C/C%12=C(C(Br)=C(C(OC)=C%12)OC)Br.F[P-](F)(F)(F)(F)F
Molecular Formula
C42H30Br2F6N9O2PRuS
Molecular Weight
1130.65
References & Citations
[1]Yang Y, et al. Study on the Multimodal Anticancer Mechanism of Ru (II) /Ir (III) Complexes Bearing a Poly (ADP-ribose) Polymerase 1 Inhibitor. J Med Chem. 2023;66 (19) :13731-13745.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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