GK718

GK718 is a HDAC1/3 inhibitor (IC50: 259 and 139 nM respectively) . GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice[1].

Product Specifications

CAS Number

[3032392-65-4]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gk718.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]1NCCC1)NCC2=CC=C(OCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)C=C2.Cl.Cl

Molecular Formula

C26H30Cl2N4O3

Molecular Weight

517.45

References & Citations

[1]Gerokonstantis DT, et al. N- (2-Aminophenyl) -benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity. J Med Chem. 2023 Oct 26;66 (20) :14357-14376.