Tubulin polymerization-IN-51

Tubulin polymerization-IN-51 (compound 7u) is a tubulin polymerization inhibitor with IC50 value of 2.55 - 17.89μM for SK-Mel-28 cells. Tubulin polymerization-IN-51 can be used for cancer research[1].

Product Specifications

CAS Number

[2998928-27-9]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-51.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(C2=NC3=C(N2)C=CC(C)=C3)=CC=C1OCC(N4CC5=C(C=CC=C5)CC4)=O

Molecular Formula

C26H25N3O3

Molecular Weight

427.50

References & Citations

[1]Laxmikeshav K, et al. Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies. Bioorg Med Chem Lett. 2023 Oct 3;96:129494.