NKG2D-IN-2

NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively[1].

Product Specifications

UNSPSC

12352005

Target

C-type Lectin-like Receptors (CTLRs)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nkg2d-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C1=CC(C(F)(F)F)=C(Cl)C(Cl)=C1)C(N(C)C)=O)C2=C(C3=CC=C(C(F)(F)F)C=C3)C=CN=C2

Molecular Formula

C24H17Cl2F6N3O2

Molecular Weight

564.31

References & Citations

[1]Jocelyn Wang, et al. Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D) . Bioorg Med Chem Lett. 2023 Sep 29:129492.