NKG2D-IN-2
NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively[1].
Product Specifications
UNSPSC
12352005
Target
C-type Lectin-like Receptors (CTLRs)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nkg2d-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C1=CC(C(F)(F)F)=C(Cl)C(Cl)=C1)C(N(C)C)=O)C2=C(C3=CC=C(C(F)(F)F)C=C3)C=CN=C2
Molecular Formula
C24H17Cl2F6N3O2
Molecular Weight
564.31
References & Citations
[1]Jocelyn Wang, et al. Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D) . Bioorg Med Chem Lett. 2023 Sep 29:129492.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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