NKG2D-IN-1

NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.3 µM and 0.7 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively[1].

Product Specifications

UNSPSC

12352005

Target

C-type Lectin-like Receptors (CTLRs)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nkg2d-in-1.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1N=CC=C1C2=CC(C(NC(C(N(C)C)=O)C3=CC=CC(C(F)(F)F)=C3)=O)=C(C4=CC=C(C(F)(F)F)C=C4)C=C2

Molecular Formula

C29H24F6N4O2

Molecular Weight

574.52

References & Citations

[1]Jocelyn Wang, et al. Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D) . Bioorg Med Chem Lett. 2023 Sep 29:129492.