TGR5 agonist 4
TGR5 agonist 4 (compound 19), a cholic acid derivative, is a selective TGR5 agonist with an EC50 of 4 μM[1].
Product Specifications
UNSPSC
12352211
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tgr5-agonist-4.html
Solubility
10 mM in DMSO
Smiles
FC(F)(C[C@H]([C@]1(CC[C@]2([C@@]3([C@@H](C[C@@]4(C[C@@H](CC[C@@]4([C@]3(C[C@@H]([C@@]21C)O)[H])C)O)[H])O)[H])[H])[H])C)C(O)=O
Molecular Formula
C24H38F2O5
Molecular Weight
444.55
References & Citations
[1]Emiliano Rosatelli, et al. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives. Eur J Med Chem. 2023 Oct 1:261:115851.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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