TGR5 agonist 3
TGR5 agonist 3 (compound 8), a Cholic acid derivative, is a selective TGR5 agonist with an EC50 of 5 μM[1].
Product Specifications
CAS Number
2148317-51-3
UNSPSC
12352211
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tgr5-agonist-3.html
Solubility
10 mM in DMSO
Smiles
C[C@@H]([C@]1(CC[C@]2([C@@]3([C@](O)(C[C@@]4(C[C@@H](CC[C@@]4([C@]3(C[C@@H]([C@]12C)O)[H])C)O)[H])CCCC)[H])[H])[H])CCC(O)=O
Molecular Formula
C28H48O5
Molecular Weight
464.68
References & Citations
[1]Emiliano Rosatelli, et al. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives. Eur J Med Chem. 2023 Oct 1:261:115851.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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