BuChE-IN-9
Product Specifications
UNSPSC Description
BuChE-IN-9 (compound 22a) is a potent equine serum-derived BuChE (eqBuChE) inhibitor with an IC50 of 173 nM. BuChE-IN-9 also inhibits human BACE1, Aβ aggregation, mouse GABA transporter 1 (mGAT1) and mGAT4. BuChE-IN-9 has significant antiamnesic properties[1].
Target Antigen
Beta-secretase; Cholinesterase (ChE); GABA Receptor
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-9.html
Solubility
10 mM in DMSO
Smiles
CN(C(CCN)C(NCC1=CC=CC=C1)=O)CCOCCN2C(C=CC=C3)=C3C4=C2C=CC=C4
Molecular Weight
458.60
References & Citations
[1]Paula Zaręba, et al. Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease. Eur J Med Chem. 2023 Oct 7:261:115832.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155305/BuChE-IN-9-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155305/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
