BuChE-IN-8

BuChE-IN-8 (compound 19c) is a butyrylcholinesterase (BuChE) inhibitor with an IC50 of 559 nM. BuChE-IN-8 possesses human β-secretase (BACE1) and Aβ40 aggregation inhibitory activities. BuChE-IN-8 has significant antiamnesic properties[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/buche-in-8.html

Solubility

10 mM in DMSO

Smiles

CN(C(CCN)C(NCC1=CC=C(Cl)C=C1)=O)CCOCCN2C3=C(C=CC=C3)SC4=CC=CC=C42

Molecular Formula

C28H33ClN4O2S

Molecular Weight

525.11

References & Citations

[1]Paula Zaręba, et al. Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease. Eur J Med Chem. 2023 Oct 7:261:115832.