FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor with IC50 values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L[1].
Product Specifications
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-in-22.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H]1CC[C@H](N)C1)C2=CC=C(NN=C3C4=NC5=C(C=C(C6=COC=C6)C=C5)N4)C3=C2
Molecular Formula
C24H22N6O2
Molecular Weight
426.47
References & Citations
[1]Bongki Ko, et al. Discovery of benzimidazole-indazole derivatives as potent FLT3-tyrosine kinase domain mutant kinase inhibitors for acute myeloid leukemia. European Journal of Medicinal Chemistry. 7 October 2023, 115860.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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