PITB

PITB is a selective and orally active transthyretin (TTR) aggregation inhibitor. PITB can be used for transthyretin amyloidosis (ATTR) disease research[1].

Product Specifications

UNSPSC

12352005

Target

Transthyretin (TTR)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pitb.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(O)=CC(F)=C1)C2=CC(OC)=C(O)C([N+]([O-])=O)=C2

Molecular Formula

C14H10FNO6

Molecular Weight

307.23

References & Citations

[1]Francisca Pinheiro, et al. PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur J Med Chem. 2023 Oct 6:261:115837.