SARS-CoV-2-IN-60

SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM) -competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 μM and a Ki of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics[1].

Product Specifications

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-2-in-60.html

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(/C=C/C2=NC(O)=NC(C(F)(F)F)=C2)C(Cl)=C1

Molecular Formula

C13H7Cl2F3N2O

Molecular Weight

335.11

References & Citations

[1]Nicole L Inniss, et al. Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors. ACS Infect Dis. 2023 Oct 13;9 (10) :1918-1931.