Pomalidomide-5-C8-NH2 (hydrochloride)
Pomalidomide-5-C8-NH2 hydrochloride is the Pomalidomide (HY-10984) -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C8-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].
Product Specifications
CAS Number
[2863635-03-2]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-5-c8-nh2-hydrochloride.html
Purity
99.34
Solubility
10 mM in DMSO
Smiles
O=C1C(C=CC(NCCCCCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl
Molecular Formula
C21H29ClN4O4
Molecular Weight
436.93
References & Citations
[1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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