Pomalidomide-5-C5-NH2 (hydrochloride)

Pomalidomide-5-C5-NH2 hydrochloride is the Pomalidomide (HY-10984) -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].

Product Specifications

CAS Number

[2925306-39-2]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-5-c5-nh2-hydrochloride.html

Purity

97.58

Solubility

10 mM in DMSO

Smiles

O=C1C(C=CC(NCCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl

Molecular Formula

C18H23ClN4O4

Molecular Weight

394.85

References & Citations

[1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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