12R-LOX-IN-1
12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod -induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].
Product Specifications
CAS Number
857758-13-5
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12r-lox-in-1.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(N=C(C2=CC=CC=C2O)C=C3)C3=C1
Molecular Formula
C15H11NO2
Molecular Weight
237.25
References & Citations
[1]Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX) : Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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