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VEGFR-2-IN-36

VEGFR-2-IN-36 (compound 15) is a VEGFR-2 inhibitor (IC50: 0.067 μM) and inducer of apoptosis with anticancer activity. VEGFR-2-IN-36 upregulates BAX levels and downregulates Bcl-2 levels. VEGFR-2-IN-36 is toxic to cancer cells, MCF-7 (IC50=0.42 μM) and HepG2 (IC50=0.22 μM) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-36.html

Solubility

10 mM in DMSO

Smiles

CN(C=N1)C2=C1N(C)C(N(CC(NC3=CC=C(/C(C)=N/NC(C4=CC=C(O)C=C4)=O)C=C3)=O)C2=O)=O

Molecular Formula

C24H23N7O5

Molecular Weight

489.48

References & Citations

[1]Eissa IH, et al. Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and apoptosis inducers. Comput Biol Chem. 2023 Aug 30;107:107953.. .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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