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VEGFR-2-IN-35

VEGFR-2-IN-35 (compound 7) is a potent VEGFR-2 inhibitor with IC50=37 nM. VEGFR-2-IN-35 inhibits MCF-7 and HCT 116 cancer cells with IC50 values of 10.56 and 7.07 μM, respectively[1].

Product Specifications

CAS Number

[2634356-52-6]

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-35.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(NC(C2=CC=CC=C2)=O)C=C1)N/N=C/C3=CC(C=CC=C4)=C4C=C3O

Molecular Formula

C25H19N3O3

Molecular Weight

409.44

References & Citations

[1]Elkaeed EB, et al. In silico, in vitro VEGFR-2 inhibition, and anticancer activity of a 3- (hydrazonomethyl) naphthalene-2-ol derivative. J Biomol Struct Dyn. 2023 Sep-Oct;41 (16) :7986-8001.. .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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