LIN28-IN-1

LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD) . LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM) [1].

Product Specifications

UNSPSC

12352005

Target

MicroRNA

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lin28-in-1.html

Solubility

10 mM in DMSO

Smiles

OC(C1=CC=C(N2C(C(C=C([N+]([O-])=O)C(N3CCN(C(OCC4=CC=CC=C4)=O)CC3)=C5)=C5OC67CCN(CC8=CC=CC=C8)CC7)=C6C=N2)C=C1)=O

Molecular Formula

C40H38N6O7

Molecular Weight

714.77

References & Citations

[1]Borgelt L, et al. Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-Binding Protein LIN28 and Let-7. Chembiochem. 2023 Sep 1;24 (17) :e202300168.. .