LIN28-IN-1
Product Specifications
UNSPSC Description
LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM)[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/lin28-in-1.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=C(N2C(C(C=C([N+]([O-])=O)C(N3CCN(C(OCC4=CC=CC=C4)=O)CC3)=C5)=C5OC67CCN(CC8=CC=CC=C8)CC7)=C6C=N2)C=C1)=O
Molecular Weight
714.77
References & Citations
[1]Borgelt L, et al. Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-Binding Protein LIN28 and Let-7. Chembiochem. 2023 Sep 1;24(17):e202300168.. .
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155237/LIN28-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155237/
Clinical Information
No Development Reported
Curated Selection
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