Neutrophil elastase inhibitor 4
Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM) . Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC50s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells[1].
Product Specifications
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/neutrophil-elastase-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N(CC1=C2C=CC=C1N3C(C(CC)(CC)C3=O)=O)C2=O)CC4)NC4=O
Molecular Formula
C20H21N3O5
Molecular Weight
383.40
References & Citations
[1]Donarska B, et al. Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action. Bioorg Chem. 2023 Sep;138:106608.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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