ALK/EGFR-IN-3
Product Specifications
UNSPSC Description
ALK/EGFR-IN-3 is a dual inhibitor of ALK and EGFR. ALK/EGFR-IN-3 inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.1360, 0.0332, and 0.0339 μM, respectively[1].
Target Antigen
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk-egfr-in-3.html
Solubility
10 mM in DMSO
Smiles
O=[S@@](CC)C1=C(NC2=NC(NC3=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C3)=NC=C2Cl)C=CC=C1
Molecular Weight
572.12
References & Citations
[1]An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155227B/ALK-EGFR-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155227B/
Clinical Information
No Development Reported
CAS Number
2730432-72-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
