FLT3-IN-21
FLT3-IN-21 (compound LC-3) is a potent FLT3 inhibitor (IC50: 8.4 nM) and induces apoptosis. FLT3-IN-21 can arrest the cell cycle in the G1 phase and inhibit the proliferation of FLT3-ITD-positive AML cells MV-4-11 (IC50: 5.3 nM) . In mice, FLT3-IN-21 (10 mg/kg/d) inhibited tumor growth in the MV-4-11 xenograft model (TGI=92.16%) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FLT3
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-in-21.html
Solubility
10 mM in DMSO
Smiles
CC1=C(NC=C1NC(NN2CCCCC2)=O)/C=C(C3=CC(F)=CC=C3N4)\C4=O
Molecular Formula
C20H22FN5O2
Molecular Weight
383.42
References & Citations
[1]Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645.|[2]Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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