MTOR inhibitor-13
MTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1].
Product Specifications
CAS Number
[1144075-44-4]
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-13.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=NC3=C(C(N4C[C@@H]5O[C@@H](CC5)C4)=N2)SC=C3)C=C1)NC6=CC=CN=C6
Molecular Formula
C24H22N6O2S
Molecular Weight
458.54
References & Citations
[1]Jeroen C Verheijen, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20 (1) :375-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
48557116 3x 1.0 µg
Tsga10ip sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
Sign In for Pricing
View Details 033759-ML550 100 µL
CELA3A, ID (CELA3A, ELA3, ELA3A, Chymotrypsin-like elastase family member 3A, Elastase IIIA, Elastase-3A, Protease E) (MaxLight 550) discontinued
Sign In for Pricing
View Details 
MBS6191972-01 0.1 mL
PPP6C (PPP6, Serine/Threonine-protein Phosphatase 6 Catalytic Subunit, FLJ92648, MGC12249) (MaxLight 405)
Sign In for Pricing
View Details MBS6191972-02 5x 0.1 mL
PPP6C (PPP6, Serine/Threonine-protein Phosphatase 6 Catalytic Subunit, FLJ92648, MGC12249) (MaxLight 405)
Sign In for Pricing
View Details abx335388-01 20 µg
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody (HRP)
Sign In for Pricing
View Details 
abx335388-02 50 µg
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody (HRP)
Sign In for Pricing
View Details