MTOR inhibitor-13

MTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1].

Product Specifications

CAS Number

[1144075-44-4]

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mtor-inhibitor-13.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C2=NC3=C(C(N4C[C@@H]5O[C@@H](CC5)C4)=N2)SC=C3)C=C1)NC6=CC=CN=C6

Molecular Formula

C24H22N6O2S

Molecular Weight

458.54

References & Citations

[1]Jeroen C Verheijen, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20 (1) :375-9.