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Antileishmanial agent-23

Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC50 of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei[1].

Product Specifications

CAS Number

745033-86-7

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-23.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1)C2=NCC(S2)CSC3=NN=C(C4=CC5=C(OCO5)C=C4)O3

Molecular Formula

C20H17N3O4S2

Molecular Weight

427.50

References & Citations

[1]Ilari A, et al. Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors. Mol Pharm. 2018 Aug 6;15 (8) :3069-3078.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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