Anticancer agent 154
Product Specifications
UNSPSC Description
Anticancer agent 154 (Compound 8h) increases the levels of reactive oxygen species and leads to mitochondrial damage. Anticancer agent 154 induces cell apoptosis and DNA damage. Anticancer agent 154 also induces ferroptosis by reducing the GSH level and GPX4 expression and increasing the lipid peroxidation level. Anticancer agent 154 inhibits cancer cell (HT29, H1975, A549, and MCF-7) proliferation with IC50s of 1.0-1.9 μM[1].
Target Antigen
Apoptosis; Ferroptosis; Reactive Oxygen Species
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-154.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C1)N2C3=CC=CC=C3C4=C2C1=NC(C(NCCN5CCN(C)CC5)=O)=C4
Molecular Weight
389.45
References & Citations
[1]Ding J, et al. Novel Canthin-6-one Derivatives: Design, Synthesis, and Their Antiproliferative Activities via Inducing Apoptosis, Deoxyribonucleic Acid Damage, and Ferroptosis. ACS Omega. 2023 Aug 18;8(34):31215-31224.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155203/Anticancer-agent-154-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155203/
Clinical Information
No Development Reported
CAS Number
9007-83-4
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