YJ182
YJ182 is a NDM-1 inhibitor (IC50: 0.23 μM) . YJ182 also inhibits IMP-1, VIM-2, GIM-1, and MMP-2, with IC50s of 0.25, 0.61, 0.49, and 6.92 μM respectively. YJ182 can be used for bacterial infection research[1].
Product Specifications
CAS Number
3035446-91-1
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/yj182.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=NC2=C(NS(=O)(C3=CC=CC=N3)=O)C=CC=C2C(C4=CC=CC=C4)=C1
Molecular Formula
C21H15N3O4S
Molecular Weight
405.43
References & Citations
[1]Jia Y, et al. Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems. J Med Chem. 2023 Sep 14;66 (17) :11761-11791.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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