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EGFR-IN-84

EGFR-IN-84 (Compound 6g) is an EGFR inhibitor (IC50: 24 nM) . EGFR-IN-84 inhibits A549 cell growth (IC50: 1.537 μM) . EGFR-IN-84 can be used for research of lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-84.html

Solubility

10 mM in DMSO

Smiles

O=C(CSC1=NN=C(NC2=CC=CC=C2)S1)N(C(C3=CC=C([N+]([O-])=O)C=C3)C4)N=C4C5=CC=CC=C5

Molecular Formula

C25H20N6O3S2

Molecular Weight

516.59

References & Citations

[1]Kurban B, et al. Synthesis and Anticancer Activities of Pyrazole-Thiadiazole-Based EGFR Inhibitors. ACS Omega. 2023 Aug 17;8 (34) :31500-31509.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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