PDE1-IN-5
PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50: 15 nM) . PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS) -Induced colitis mice model. PDE1-IN-5 can be used for research of IBD[1].
Product Specifications
CAS Number
2982945-34-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde1-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C#N)=C(C2=CC=C(C=C2N1CC3CCCC3)NCC4=CC=C(C=N4)F)C5CCCC5
Molecular Formula
C27H29FN4O
Molecular Weight
444.54
References & Citations
[1]Zhang B, et al. Identification of Novel Quinolin-2 (1H) -ones as Phosphodiesterase 1 Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2023 Sep 14;66 (17) :12468-12478.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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