PDE1-IN-5
PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50: 15 nM) . PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS) -Induced colitis mice model. PDE1-IN-5 can be used for research of IBD[1].
Product Specifications
CAS Number
2982945-34-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde1-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C#N)=C(C2=CC=C(C=C2N1CC3CCCC3)NCC4=CC=C(C=N4)F)C5CCCC5
Molecular Formula
C27H29FN4O
Molecular Weight
444.54
References & Citations
[1]Zhang B, et al. Identification of Novel Quinolin-2 (1H) -ones as Phosphodiesterase 1 Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2023 Sep 14;66 (17) :12468-12478.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
588024 96 Tests
S100 Calcium Binding Protein B (S100B) BioAssayTM ELISA Kit (Sheep) discontinued
Sign In for Pricing
View Details 
TRV-0026143 96 Tests
Multiplex Assay Kit for Sex Determining Region Y Box Protein 1 (SOX1), etc. by FLIA (Flow Luminescence Immunoassay)
Sign In for Pricing
View Details 