ER degrader 6
ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER) α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness[1].
Product Specifications
CAS Number
2922929-62-0
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/er-degrader-6.html
Solubility
10 mM in DMSO
Smiles
O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1
Molecular Formula
C33H34FN3O5SSe
Molecular Weight
682.66
References & Citations
[1]Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66 (16) :11094-11117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
Frequently Asked Questions
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