ER degrader 6
ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER) α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness[1].
Product Specifications
CAS Number
2922929-62-0
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/er-degrader-6.html
Solubility
10 mM in DMSO
Smiles
O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1
Molecular Formula
C33H34FN3O5SSe
Molecular Weight
682.66
References & Citations
[1]Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66 (16) :11094-11117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K4475405 3x 1.0 µg
Foxp1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details 
CSB-EL006414HU-01 24 Well
Human Cytochrome P450 2B6 (CYP2B6) ELISA kit
Sign In for Pricing
View Details CSB-EL006414HU-02 96 Well
Human Cytochrome P450 2B6 (CYP2B6) ELISA kit
Sign In for Pricing
View Details CSB-EL006414HU-03 5x 96 Well
Human Cytochrome P450 2B6 (CYP2B6) ELISA kit
Sign In for Pricing
View Details