IIIM-8

IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM) . IIIM-8 can be used for hyperpigmentation disorders research[1].

Product Specifications

CAS Number

[1128053-62-2]

UNSPSC

12352005

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/iiim-8.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C(C)=O)C(O)=C(C2=CCN(C)CC2)C(O)=C1

Molecular Formula

C14H17NO4

Molecular Weight

263.29

References & Citations

[1]Naikoo SH, et al. Inhibition of melanogenesis by 3- (1'-methyltetrahydropyridinyl) -2,4-6-trihydroxy acetophenone via suppressing the activity of cAMP response element-binding protein (CREB) and nuclear exclusion of CREB-regulated transcription coactivator 1 (CRTC1) . Eur J Pharmacol. 2023 Aug 5;952:175734.