NMDA receptor antagonist 8
NMDA receptor antagonist 8 (Compound (R) -10a) is GluN2B subunit-selective NMDA Receptor antagonist, with an Ki of 265 nM and an IC50 of 62 nM. NMDA receptor antagonist 8 can be used for research of neurodegenerative diseases[1].
Product Specifications
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nmda-receptor-antagonist-8.html
Solubility
10 mM in DMSO
Smiles
O[C@H](CCN1CCC(CC2=CC=CC=C2)CC1)C3=CC(C=NN4)=C4C=C3
Molecular Formula
C22H27N3O
Molecular Weight
349.47
References & Citations
[1]Lüken J, et al. Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists. J Med Chem. 2023 Aug 24;66 (16) :11573-11588.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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