NMDA receptor antagonist 7
Product Specifications
UNSPSC Description
NMDA receptor antagonist 7 (Compound (S)-10a) is GluN2B subunit-selective NMDA Receptor antagonist, with an Ki of 93 nM and an IC50 of 72 nM. NMDA receptor antagonist 7 can be used for research of neurodegenerative diseases[1].
Target Antigen
iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nmda-receptor-antagonist-7.html
Solubility
10 mM in DMSO
Smiles
O[C@@H](CCN1CCC(CC2=CC=CC=C2)CC1)C3=CC(C=NN4)=C4C=C3
Molecular Weight
349.47
References & Citations
[1]Lüken J, et al. Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists. J Med Chem. 2023 Aug 24;66(16):11573-11588.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155185/NMDA-receptor-antagonist-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155185/
Clinical Information
No Development Reported
Curated Selection
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