NMDA receptor antagonist 7

NMDA receptor antagonist 7 (Compound (S) -10a) is GluN2B subunit-selective NMDA Receptor antagonist, with an Ki of 93 nM and an IC50 of 72 nM. NMDA receptor antagonist 7 can be used for research of neurodegenerative diseases[1].

Product Specifications

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nmda-receptor-antagonist-7.html

Solubility

10 mM in DMSO

Smiles

O[C@@H](CCN1CCC(CC2=CC=CC=C2)CC1)C3=CC(C=NN4)=C4C=C3

Molecular Formula

C22H27N3O

Molecular Weight

349.47

References & Citations

[1]Lüken J, et al. Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists. J Med Chem. 2023 Aug 24;66 (16) :11573-11588.