HDAC-IN-62
HDAC-IN-62 (Compound 5) a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2 μM for HDAC6/8/11 respectively. HDAC-IN-62 inhibits-induced microglial activation by the initiation of autophagy, and inhibits nitric oxide production. HDAC-IN-62 has anti-inflammatory and anti-depressant effects. HDAC-IN-62 inhibits microglial activation in mouse brain[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; HDAC
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hdac-in-62.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C/C1=CC=C(/C=C/C(NO)=O)N1C)C2=CC=CS2
Molecular Formula
C15H14N2O3S
Molecular Weight
302.35
References & Citations
[1]Baek SY, et al. Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation. Biomed Pharmacother. 2023 Aug 9;166:115312.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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