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ZMF-23

ZMF-23 is a PAK1/HDAC6 dual inhibitor. ZMF-23 inhibits PAK1 and HDAC6 regulated aerobic glycolysis and migration. ZMF-23 induces TNF-α-regulated necroptosis, and further enhances apoptosis. ZMF-23 inhibits the Warburg effect and cell migration. ZMF-23 can be used for research of triple-negative breast cancer (TNBC) [1].

Product Specifications

UNSPSC

12352005

Target

HDAC; PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zmf-23.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(Cl)=CC=C1C2=CC3=CN=C(NC4CC4)N=C3N(CCCCCC(NO)=O)C2=O

Molecular Formula

C22H23Cl2N5O3

Molecular Weight

476.36

References & Citations

[1]Zhang J, et al. ZMF-23 that triggers tubulin-stathmin regulated cell death in triple negative breast cancer. Int J Biol Macromol. 2023 Aug 14;251:126348.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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