COX-2/15-LOX-IN-3

COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity[1].

Product Specifications

UNSPSC

12352005

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-15-lox-in-3.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C(OC)=CC(C2=NC3=C(C(CCCC4)=C4S3)C(NC5=CC=C(F)C=C5)=N2)=C1

Molecular Formula

C25H24FN3O3S

Molecular Weight

465.54

References & Citations

[1]Elsayed S, et al. Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity. Eur J Med Chem. 2023 Aug 15;260:115724.