COX-2/15-LOX-IN-3
Product Specifications
UNSPSC Description
COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity[1].
Target Antigen
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-15-lox-in-3.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C(OC)=CC(C2=NC3=C(C(CCCC4)=C4S3)C(NC5=CC=C(F)C=C5)=N2)=C1
Molecular Weight
465.54
References & Citations
[1]Elsayed S, et al. Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity. Eur J Med Chem. 2023 Aug 15;260:115724.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155160/COX-2-15-LOX-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155160/
Clinical Information
No Development Reported
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