Anticancer agent 147
Product Specifications
UNSPSC Description
Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-147.html
Solubility
10 mM in DMSO
Smiles
COC(CCC[C@]1([H])[C@]2([H])[C@]3([H])[C@@](CCCN3CCC2)([H])CN1CC(C4=C5C=CC=C4)=CN5CC6=CC=C(Br)C=C6)=O
Molecular Weight
578.58
References & Citations
[1]Tian K, et al. Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. Cell Death Discov. 2023 Aug 14;9(1):296..
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155158/Anticancer-agent-147-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155158/
Clinical Information
No Development Reported
CAS Number
9007-83-4
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