P-gp/BCRP-IN-2
P-gp/BCRP-IN-2 (compound 15) is an oxadiazole derivative and a dual inhibitor of the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). P-gp/BCRP-IN-2 also enhances the anti-proliferative effects of Doxorubicin in drug-resistant human adenocarcinoma colon cancer cell lines HT29/DX and MDCK-MDR1 cells[1].
Product Specifications
UNSPSC
12352005
Target
BCRP; P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-bcrp-in-2.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(/C=C/C2=NN=C(O2)C(C=C3)=CC=C3CCN4CCC5=CC(OC)=C(OC)C=C5C4)=CC(OC)=C1OC
Molecular Formula
C32H35N3O6
Molecular Weight
557.64
References & Citations
[1]Braconi L, et al. Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers. Eur J Med Chem. 2023 Nov 5;259:115716..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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