RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent dual RIPK2/3 kinases inhibitor with IC50 values of 3 nM and 117 nM, respectively. RIPK2/3-IN-1 is against RIPK2 with IC50 value 14 nM in 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay[1].
Product Specifications
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk2-3-in-1.html
Solubility
10 mM in DMSO
Smiles
OCC1=CC=C(O1)C2=CC3=C(C=C2C4=CC=CS4)C(NC5=CC(N=CS6)=C6C=C5)=NC=N3
Molecular Formula
C24H16N4O2S2
Molecular Weight
456.54
References & Citations
[1]Mbilo Misehe, et al. Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases .Eur J Med Chem. 2023 Nov 15;260:115717.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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