MAT2A-IN-12

MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC50 of 5 nM. MAT2A Allosteric inhibitor 2 shows nanomolar activity (IC50=5 μM) in the the proliferation assay (MTAP-/- cell line) [1].

Product Specifications

CAS Number

631897-75-1

UNSPSC

12352005

Target

Methionine Adenosyltransferase (MAT)

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mat2a-in-12.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(OC2=C3C=C(OC)C=C2)=C3C(C4=CC=C(C)C=C4)=[N+]1[O-]

Molecular Formula

C20H17NO3

Molecular Weight

319.35

References & Citations

[1]Tuomo Kalliokoski, et al. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg Med Chem Lett . 2023 Oct 1;94:129450