Anticancer agent 146

Anticancer agent 146 (compound 1.19) is a necroptosis inducer. Anticancer agent 146 has anti-tumor efficacy in the mouse MDA-MB-231 xenograft model[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Necroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-146.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(N2CCNCC2)C=C1)C3=CC4=CC(Cl)=CC(Cl)=C4O3

Molecular Formula

C19H16Cl2N2O2

Molecular Weight

375.25

References & Citations

[1]Schumacher TJ, et al. Synthesis and biological evaluation of benzofuran piperazine derivatives as potential anticancer agents. Bioorg Med Chem Lett. 2023 Sep 1;93:129425..