GLS1 Inhibitor-7

GLS1 Inhibitor-7 (compound 4d) is a GLS1 inhibitor (IC50=46.7 μM), with potential anti-cancer, anti-aging and anti-obesity properties[1].

Product Specifications

UNSPSC

12352005

Target

Glutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gls1-inhibitor-7.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(CNC(CSC2=NN=C(NC(C3=CC=C(C(F)(F)F)C=C3)=O)S2)=O)C=C1

Molecular Formula

C20H17F3N4O3S2

Molecular Weight

482.50

References & Citations

[1]Okada T, et al. Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity. Bioorg Med Chem Lett. 2023 Sep 1;93:129438.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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