PARP-1-IN-13

PARP-1-IN-13 (Compound 19c) is a PARP-1 inhibitor (IC50: 26 nM) . PARP-1-IN-13 inhibits DNA single-strand breakage repair and aggravates DNA double-strand breakage. PARP-1-IN-13 promotes the apoptosis of cancer cells through the mitochondrial apoptosis pathway[1].

Product Specifications

CAS Number

[2999661-74-2]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp-1-in-13.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(C2=CC=C(/C=N/NC(NCC)=S)C=C2)=NC3=C1OC4=C3C=CC=C4

Molecular Formula

C20H17N5O2S

Molecular Weight

391.45

References & Citations

[1]Yuanjiang Wang, et al. Design, synthesis, and biological evaluation of a series of benzofuran[3,2-d]pyrimidine-4 (3H) -one derivatives containing thiosemicarbazone analogs as novel PARP-1 inhibitors. Bioorganic Chemistry. Volume 139, October 2023, 106759.