EGFR-IN-81
EGFR-IN-81 (Compound 10i) is an EGFR inhibitor. EGFR-IN-81 inhibits EGFR WT and L858R/T790M with IC50s 4.38 nM and 5.69 nM. EGFR-IN-81 has cytotoxic activity against MCF-7 and HCT116 cells with of 2.07 μM and 6.72 μM respectively[1].
Product Specifications
CAS Number
2968419-65-8
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-81.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC=C(NC(C2=CC=C(N(CCC3=CC=C(O)C=C3)C(NC4C(NC(CC4)=O)=O)=N5)C5=C2)=O)C=C1
Molecular Formula
C28H24F3N5O4
Molecular Weight
551.52
References & Citations
[1]Cynthia E Theodore, et al. Design, synthesis, anticancer activity and molecular docking of novel 1H-benzo[d]imidazole derivatives as potential EGFR inhibitors. Journal of Molecular Structure. Volume 1294, Part 2, 15 December 2023, 136341.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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