5-HT6 agonist 1

5-HT6 agonist 1 (Compound 19) is a 5-HT6 agonist (Ki: 5 nM) . 5-HT6 agonist 1 has antidepressant-like properties, and improves cognitive deficits. 5-HT6 agonist 1 also inhibits platelet aggregation. 5-HT6 agonist 1 has high metabolic stability[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-ht6-agonist-1.html

Solubility

10 mM in DMSO

Smiles

CCC(C1=NC(N)=NC(N2CCN(C)CC2)=N1)SC3=C(Cl)C=CC(Cl)=C3

Molecular Formula

C17H22Cl2N6S

Molecular Weight

413.37

References & Citations

[1]Czarnota-Łydka K, et al. Synthesis, computational and experimental pharmacological studies for (thio) ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease. Eur J Med Chem. 2023 Nov 5;259:115695.