HIV-1 inhibitor-59

HIV-1 inhibitor-59 (Compound I-5b) is a HIV-1 inhibitor, with EC50s of 5.62-171 nM against the wild-type (WT) and mutant HIV-1 strains. HIV-1 inhibitor-59 has moderate RT enzyme inhibitory activity (IC50: 0.094-12.0 μM) [1].

Product Specifications

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-59.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC(C)=C(OC2=C(F)C=C(C#N)C(NC3CCN(CC4=CC=C(S(C)(=O)=O)C=C4)CC3)=N2)C(C)=C1

Molecular Formula

C28H28FN5O3S

Molecular Weight

533.62

References & Citations

[1]Song H, et al. 5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation. Eur J Med Chem. 2023 Nov 5;259:115686.